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Alien invasion (surprisingly common)
Badass climax or fight scene(s)
Beloved character fucking dies
Characters get final hurrah episodes
Characters get updated/new designs
Epilogue speech/episode after finale
Final shot with main characters
Gay couple/character revealed
Hero obtains ultimate power or something
Inconclusive arcs
Massive tonal shift from previous seasons
New episodic format
Rapid callbacks and cameos
Relationship developing episode(s)
Series gets screwed by network
Series goes out on a whimper
Series reaches natural conclusion
Shift in animation quality
Someone re-learns old lesson
Story continued by later media or spin-off
Time skip
Ultimate villain surpassing every previous one
Villain redemption or heroic corruption